COPRS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0007517Biological processmuscle organ development
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameCOPRS
Protein nameCoordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1)
Coordinator of PRMT5 and differentiation stimulator
SynonymsCOPR5
C17orf79
DescriptionFUNCTION: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). .

AccessionsJ3QRX9
J3QRX6
ENST00000496655.1
ENST00000579741.1
ENST00000302362.11
H9KV77
ENST00000378634.6
Q9NQ92
ENST00000579984.1
J3QRX4