CNTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007219Biological processNotch signaling pathway
GO_0010976Biological processpositive regulation of neuron projection development
GO_0010628Biological processpositive regulation of gene expression
GO_0032289Biological processcentral nervous system myelin formation
GO_0007155Biological processcell adhesion
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0021549Biological processcerebellum development
GO_0007420Biological processbrain development
GO_0010467Biological processgene expression
GO_0098609Biological processcell-cell adhesion
GO_0007626Biological processlocomotory behavior
GO_0007411Biological processaxon guidance
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0042734Cellular componentpresynaptic membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0098552Cellular componentside of membrane
GO_0030424Cellular componentaxon
GO_0098632Molecular functioncell-cell adhesion mediator activity
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCNTN1
Protein nameContactin 1
Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
Synonyms
DescriptionFUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). .

AccessionsENST00000552248.5
ENST00000551424.5
ENST00000347616.5 [Q12860-1]
ENST00000547702.5 [Q12860-3]
F8VUI8
ENST00000552913.5
Q12860
ENST00000548005.5
ENST00000548481.1
F8VUI9
ENST00000348761.2 [Q12860-2]
H0YIJ1
ENST00000547849.6 [Q12860-3]
ENST00000551295.7 [Q12860-1]
F8VX96
F8VQW3