Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 26% ± 11% | |
| interneuron | 5 studies | 31% ± 16% | |
| oligodendrocyte precursor cell | 5 studies | 26% ± 9% | |
| GABAergic neuron | 5 studies | 31% ± 8% | |
| macrophage | 4 studies | 21% ± 4% | |
| neuron | 4 studies | 32% ± 12% | |
| epithelial cell | 4 studies | 35% ± 5% | |
| ciliated cell | 4 studies | 29% ± 6% | |
| glutamatergic neuron | 4 studies | 42% ± 12% | |
| astrocyte | 4 studies | 27% ± 7% | |
| oligodendrocyte | 4 studies | 23% ± 6% | |
| hematopoietic precursor cell | 3 studies | 18% ± 4% | |
| microglial cell | 3 studies | 23% ± 3% | |
| basal cell | 3 studies | 25% ± 12% | |
| transit amplifying cell | 3 studies | 31% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 2107.37 | 459 / 459 | 100% | 39.61 | 1118 / 1118 |
| esophagus | 100% | 2370.26 | 1445 / 1445 | 100% | 32.63 | 183 / 183 |
| prostate | 100% | 2240.93 | 245 / 245 | 100% | 32.22 | 502 / 502 |
| brain | 100% | 1986.98 | 2640 / 2642 | 100% | 25.29 | 705 / 705 |
| lung | 100% | 2274.16 | 578 / 578 | 100% | 25.44 | 1154 / 1155 |
| intestine | 100% | 2255.84 | 966 / 966 | 100% | 23.48 | 526 / 527 |
| bladder | 100% | 2252.29 | 21 / 21 | 100% | 24.86 | 503 / 504 |
| stomach | 100% | 1571.35 | 359 / 359 | 100% | 23.22 | 285 / 286 |
| ovary | 100% | 2254.74 | 180 / 180 | 99% | 18.54 | 427 / 430 |
| uterus | 100% | 2186.68 | 170 / 170 | 99% | 29.06 | 455 / 459 |
| thymus | 100% | 2200.57 | 653 / 653 | 99% | 22.69 | 598 / 605 |
| pancreas | 100% | 957.38 | 327 / 328 | 98% | 19.88 | 174 / 178 |
| kidney | 100% | 1813.56 | 89 / 89 | 97% | 19.38 | 874 / 901 |
| skin | 100% | 2578.90 | 1809 / 1809 | 94% | 20.59 | 446 / 472 |
| adrenal gland | 100% | 1516.45 | 258 / 258 | 94% | 12.57 | 216 / 230 |
| liver | 99% | 749.30 | 224 / 226 | 67% | 7.85 | 274 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.58 | 29 / 29 |
| spleen | 100% | 2050.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 32.54 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.85 | 1 / 1 |
| blood vessel | 100% | 1813.72 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1814.81 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 1006.82 | 843 / 861 | 0% | 0 | 0 / 0 |
| muscle | 97% | 770.51 | 781 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 88% | 1475.35 | 819 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 11.97 | 70 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000289 | Biological process | nuclear-transcribed mRNA poly(A) tail shortening |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0070966 | Biological process | nuclear-transcribed mRNA catabolic process, no-go decay |
| GO_0010606 | Biological process | positive regulation of cytoplasmic mRNA processing body assembly |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0035279 | Biological process | miRNA-mediated gene silencing by mRNA destabilization |
| GO_0006417 | Biological process | regulation of translation |
| GO_0030014 | Cellular component | CCR4-NOT complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004535 | Molecular function | poly(A)-specific ribonuclease activity |
| GO_0030374 | Molecular function | nuclear receptor coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004532 | Molecular function | RNA exonuclease activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | CNOT6 |
| Protein name | CCR4-NOT transcription complex subunit 6 CNOT6 protein (cDNA, FLJ95618) CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) |
| Synonyms | CCR4a CCR4 KIAA1194 |
| Description | FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. . |
| Accessions | ENST00000504343.1 Q9ULM6 ENST00000618123.4 ENST00000261951.9 ENST00000393356.7 D6R9H6 Q8TAJ0 |