CNOT6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0070966Biological processnuclear-transcribed mRNA catabolic process, no-go decay
GO_0010606Biological processpositive regulation of cytoplasmic mRNA processing body assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0006417Biological processregulation of translation
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0004532Molecular functionRNA exonuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCNOT6
Protein nameCCR4-NOT transcription complex subunit 6
CNOT6 protein (cDNA, FLJ95618)
CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase)
SynonymsCCR4a
CCR4
KIAA1194
DescriptionFUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. .

AccessionsENST00000504343.1
Q9ULM6
ENST00000618123.4
ENST00000261951.9
ENST00000393356.7
D6R9H6
Q8TAJ0