CNGB1 | OmnibusX

Name	Number of supported studies	Average coverage
retinal rod cell	9 studies	80% ± 13%	Explore
retinal cone cell	8 studies	63% ± 16%	Explore
glutamatergic neuron	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	6 studies	54% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	91%	100.68	880 / 966	2%	0.05	9 / 527
brain	63%	452.11	1668 / 2642	10%	0.34	72 / 705
adrenal gland	27%	59.24	70 / 258	33%	4.48	77 / 230
esophagus	25%	10.23	368 / 1445	35%	5.19	64 / 183
lung	21%	11.09	121 / 578	25%	1.04	285 / 1155
ovary	0%	0	0 / 180	35%	0.93	152 / 430
bladder	5%	0.90	1 / 21	22%	0.73	111 / 504
stomach	23%	10.21	82 / 359	2%	0.03	6 / 286
tonsil	0%	0	0 / 0	24%	2.87	11 / 45
uterus	2%	0.59	3 / 170	20%	0.94	93 / 459
peripheral blood	21%	6.76	195 / 929	0%	0	0 / 0
skin	13%	7.40	239 / 1809	3%	0.07	12 / 472
pancreas	11%	3.63	36 / 328	4%	0.30	8 / 178
breast	8%	2.91	39 / 459	2%	0.03	21 / 1118
eye	0%	0	0 / 0	6%	1.44	5 / 80
kidney	1%	0.42	1 / 89	5%	0.16	45 / 901
prostate	6%	1.71	14 / 245	0%	0	0 / 502
spleen	5%	1.01	11 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.22	1 / 29
thymus	3%	0.70	18 / 653	1%	0.02	4 / 605
liver	1%	0.37	2 / 226	2%	0.55	10 / 406
adipose	1%	0.28	12 / 1204	0%	0	0 / 0
heart	1%	0.27	7 / 861	0%	0	0 / 0
blood vessel	0%	0.11	5 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007601	Biological process	visual perception
GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0006813	Biological process	potassium ion transport
GO_1990834	Biological process	response to odorant
GO_0001895	Biological process	retina homeostasis
GO_0051899	Biological process	membrane depolarization
GO_0007602	Biological process	phototransduction
GO_0035845	Biological process	photoreceptor cell outer segment organization
GO_0045494	Biological process	photoreceptor cell maintenance
GO_0010628	Biological process	positive regulation of gene expression
GO_0050911	Biological process	detection of chemical stimulus involved in sensory perception of smell
GO_0007608	Biological process	sensory perception of smell
GO_0033365	Biological process	protein localization to organelle
GO_0050908	Biological process	detection of light stimulus involved in visual perception
GO_0021630	Biological process	olfactory nerve maturation
GO_0006814	Biological process	sodium ion transport
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0006812	Biological process	monoatomic cation transport
GO_0006816	Biological process	calcium ion transport
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0099105	Biological process	ion channel modulating, G protein-coupled receptor signaling pathway
GO_0098804	Cellular component	non-motile cilium membrane
GO_0005886	Cellular component	plasma membrane
GO_0001750	Cellular component	photoreceptor outer segment
GO_0043195	Cellular component	terminal bouton
GO_1902495	Cellular component	transmembrane transporter complex
GO_0060170	Cellular component	ciliary membrane
GO_0017071	Cellular component	intracellular cyclic nucleotide activated cation channel complex
GO_0030660	Cellular component	Golgi-associated vesicle membrane
GO_0120200	Cellular component	rod photoreceptor outer segment
GO_0005272	Molecular function	sodium channel activity
GO_0030552	Molecular function	cAMP binding
GO_0030553	Molecular function	cGMP binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0015276	Molecular function	ligand-gated monoatomic ion channel activity
GO_0005223	Molecular function	intracellularly cGMP-activated cation channel activity
GO_0005222	Molecular function	intracellularly cAMP-activated cation channel activity
GO_0005515	Molecular function	protein binding
GO_0005262	Molecular function	calcium channel activity

IV. Literature review

[source]

Gene name	CNGB1
Protein name	Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP)
Synonyms	CNCG3L CNCG4 CNCG2 RCNC2
Description	FUNCTION: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; FUNCTION: Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.
Accessions	ENST00000564654.1 H3BQC3 H3BQW3 ENST00000251102.13 [Q14028-1] ENST00000562761.1 Q14028 A0A2R8Y6Y0 ENST00000564448.5 [Q14028-4] ENST00000565942.1 ENST00000311183.8 [Q14028-3]

CNGB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review