CLSPN | OmnibusX

Name	Number of supported studies	Average coverage
plasmablast	4 studies	33% ± 13%	Explore
retinal rod cell	4 studies	18% ± 2%	Explore
T cell	4 studies	23% ± 2%	Explore
natural killer cell	4 studies	37% ± 11%	Explore
CD4-positive, alpha-beta T cell	4 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	4 studies	28% ± 5%	Explore
B cell	3 studies	17% ± 3%	Explore
hematopoietic precursor cell	3 studies	21% ± 4%	Explore
transit amplifying cell	3 studies	27% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLSPN at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	90%	412.07	1624 / 1809	89%	7.06	422 / 472
lung	96%	97.26	553 / 578	79%	4.95	907 / 1155
esophagus	52%	76.35	754 / 1445	99%	10.63	182 / 183
intestine	62%	76.20	599 / 966	86%	4.91	451 / 527
stomach	55%	56.83	197 / 359	90%	5.76	256 / 286
bladder	57%	23.81	12 / 21	81%	5.35	410 / 504
breast	66%	30.63	302 / 459	72%	4.34	804 / 1118
uterus	26%	11.11	44 / 170	95%	9.32	435 / 459
spleen	100%	228.96	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.61	45 / 45
ovary	23%	13.96	41 / 180	71%	3.57	304 / 430
lymph node	0%	0	0 / 0	90%	8.48	26 / 29
peripheral blood	84%	453.29	778 / 929	0%	0	0 / 0
brain	48%	23.87	1267 / 2642	33%	1.87	233 / 705
adipose	77%	39.23	925 / 1204	0%	0	0 / 0
adrenal gland	64%	34.16	165 / 258	6%	0.24	14 / 230
thymus	55%	21.20	359 / 653	15%	1.01	91 / 605
pancreas	26%	9.17	85 / 328	34%	1.34	60 / 178
prostate	47%	19.20	115 / 245	4%	0.14	21 / 502
liver	24%	18.73	55 / 226	21%	0.83	86 / 406
blood vessel	44%	17.15	583 / 1335	0%	0	0 / 0
kidney	30%	25.88	27 / 89	8%	0.32	76 / 901
heart	30%	12.05	255 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	6%	0.16	5 / 80
muscle	5%	1.45	43 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007095	Biological process	mitotic G2 DNA damage checkpoint signaling
GO_0032147	Biological process	activation of protein kinase activity
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0033314	Biological process	mitotic DNA replication checkpoint signaling
GO_0006281	Biological process	DNA repair
GO_0000076	Biological process	DNA replication checkpoint signaling
GO_0000077	Biological process	DNA damage checkpoint signaling
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005634	Cellular component	nucleus
GO_0000217	Molecular function	DNA secondary structure binding
GO_0010997	Molecular function	anaphase-promoting complex binding
GO_0005515	Molecular function	protein binding

Gene name	CLSPN
Protein name	Claspin Claspin homolog (Xenopus laevis) CLSPN protein Claspin (hClaspin)
Synonyms
Description	FUNCTION: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation . Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins . Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS . Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components . .
Accessions	ENST00000520551.1 Q05D30 ENST00000373220.7 [Q9HAW4-2] E7ESG2 ENST00000251195.9 [Q9HAW4-3] Q1RMC5 Q9HAW4 ENST00000318121.8 [Q9HAW4-1]

CLSPN report