CLP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CLP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLP1 at tissue level.

III. Associated gene sets

GO_0070922Biological processRISC complex assembly
GO_0031124Biological processmRNA 3'-end processing
GO_0098795Biological processglobal gene silencing by mRNA cleavage
GO_0006388Biological processtRNA splicing, via endonucleolytic cleavage and ligation
GO_0021695Biological processcerebellar cortex development
GO_0000214Cellular componenttRNA-intron endonuclease complex
GO_0005849Cellular componentmRNA cleavage factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0046404Molecular functionATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO_0051736Molecular functionATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0051731Molecular functionpolynucleotide 5'-hydroxyl-kinase activity

IV. Literature review

[source]
Gene nameCLP1
Protein nameCleavage factor polyribonucleotide kinase subunit 1
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)
SynonymsHEAB
DescriptionFUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA . Its role in tRNA splicing and maturation is required for cerebellar development . Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. .

FUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. .

AccessionsENST00000681650.1 [Q92989-1]
ENST00000525602.1 [Q92989-1]
E9PL17
ENST00000533682.2 [Q92989-1]
ENST00000529430.1
E9PJM4
ENST00000529773.2
Q92989
ENST00000533905.1
E9PKV5
ENST00000302731.4 [Q92989-2]