CLEC2A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CLEC2A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLEC2A at tissue level.

III. Associated gene sets

GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0005886Cellular componentplasma membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLEC2A
Protein nameC-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
SynonymsUNQ5792/PRO19597
KACL
DescriptionFUNCTION: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. .

AccessionsQ6UVW9
ENST00000455827.2 [Q6UVW9-1]
ENST00000339766.8 [Q6UVW9-2]