CLDN18 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLDN18 at tissue level.

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0035265Biological processorgan growth
GO_0045779Biological processnegative regulation of bone resorption
GO_2001205Biological processnegative regulation of osteoclast development
GO_0071391Biological processcellular response to estrogen stimulus
GO_0007155Biological processcell adhesion
GO_0045471Biological processresponse to ethanol
GO_0042045Biological processepithelial fluid transport
GO_0016338Biological processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0120193Biological processtight junction organization
GO_0034504Biological processprotein localization to nucleus
GO_0070830Biological processbicellular tight junction assembly
GO_0048565Biological processdigestive tract development
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0048286Biological processlung alveolus development
GO_0005886Cellular componentplasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0042802Molecular functionidentical protein binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLDN18
Protein nameClaudin-18
Claudin
SynonymsUNQ778/PRO1572
DescriptionFUNCTION: Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). .; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C. neoformans infection. .; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

AccessionsENST00000343735.8 [P56856-2]
ENST00000183605.10 [P56856-1]
F8WEY4
ENST00000479660.1
P56856