CLCN5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003014Biological processrenal system process
GO_0006897Biological processendocytosis
GO_0006821Biological processchloride transport
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_1902476Biological processchloride transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0010008Cellular componentendosome membrane
GO_0045177Cellular componentapical part of cell
GO_0005765Cellular componentlysosomal membrane
GO_0015297Molecular functionantiporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLCN5
Protein nameH(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Chloride channel protein
Chloride voltage-gated channel 5
SynonymsCLCK2
DescriptionFUNCTION: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons . Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). .

AccessionsENST00000642885.1 [P51795-1]
A0A2R8YF14
A0A2R8YGW0
P51795
A0A2R8Y6C4
ENST00000646398.1
ENST00000642383.1
ENST00000376088.7 [P51795-2]
ENST00000307367.2 [P51795-1]
ENST00000482218.2
ENST00000376091.8 [P51795-2]
ENST00000643129.1
V9GYG7
ENST00000376108.7 [P51795-1]