CHTF18 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHTF18 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	1594.35	170 / 170	100%	27.56	459 / 459
ovary	100%	1772.93	180 / 180	100%	16.91	428 / 430
esophagus	99%	893.43	1432 / 1445	99%	13.83	182 / 183
bladder	100%	1056.90	21 / 21	98%	18.48	495 / 504
skin	99%	1228.85	1795 / 1809	97%	14.57	457 / 472
prostate	100%	1331.56	245 / 245	96%	8.69	481 / 502
breast	100%	1268.59	458 / 459	96%	13.49	1068 / 1118
intestine	100%	1026.72	966 / 966	95%	16.90	502 / 527
stomach	99%	748.90	357 / 359	95%	14.78	271 / 286
lung	100%	1058.79	577 / 578	92%	12.74	1067 / 1155
thymus	100%	1210.28	653 / 653	90%	9.09	544 / 605
brain	96%	1104.33	2541 / 2642	93%	11.20	658 / 705
pancreas	98%	543.16	323 / 328	89%	8.87	159 / 178
adrenal gland	100%	784.82	257 / 258	84%	6.22	193 / 230
kidney	99%	818.96	88 / 89	64%	4.58	573 / 901
liver	91%	454.10	205 / 226	67%	5.36	271 / 406
lymph node	0%	0	0 / 0	100%	20.13	29 / 29
spleen	100%	2044.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.38	45 / 45
ureter	0%	0	0 / 0	100%	20.36	1 / 1
adipose	100%	883.02	1198 / 1204	0%	0	0 / 0
blood vessel	98%	603.70	1305 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	90%	7.69	72 / 80
heart	85%	366.77	730 / 861	0%	0	0 / 0
peripheral blood	84%	1111.44	781 / 929	0%	0	0 / 0
muscle	78%	327.49	626 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0032508	Biological process	DNA duplex unwinding
GO_0006260	Biological process	DNA replication
GO_1900264	Biological process	positive regulation of DNA-directed DNA polymerase activity
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0031390	Cellular component	Ctf18 RFC-like complex
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003689	Molecular function	DNA clamp loader activity
GO_0005515	Molecular function	protein binding
GO_0017116	Molecular function	single-stranded DNA helicase activity
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0005524	Molecular function	ATP binding

Gene name	CHTF18
Protein name	Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) Chromosome transmission fidelity factor 18
Synonyms	C16orf41 CTF18
Description	FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage . .
Accessions	H3BN43 E7EXA6 Q8WVB6 H0Y7D3 ENST00000563545.1 F8WCC1 ENST00000440239.5 ENST00000262315.14 [Q8WVB6-1] ENST00000455171.6 [Q8WVB6-2] ENST00000426047.1 H3BT35 ENST00000317063.10 ENST00000631357.2 A0A0D9SF58 ENST00000569270.5

CHTF18 report