CHSY3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0050510Molecular functionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0047238Molecular functionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

IV. Literature review

[source]
Gene nameCHSY3
Protein nameChondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3)
SynonymsCHSY2
CSS3
DescriptionFUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. .

AccessionsQ70JA7
ENST00000305031.5