Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 28% ± 12% | |
| glutamatergic neuron | 9 studies | 43% ± 26% | |
| astrocyte | 8 studies | 29% ± 12% | |
| oligodendrocyte precursor cell | 8 studies | 30% ± 12% | |
| GABAergic neuron | 7 studies | 45% ± 23% | |
| macrophage | 7 studies | 27% ± 6% | |
| oligodendrocyte | 7 studies | 29% ± 9% | |
| interneuron | 6 studies | 45% ± 23% | |
| microglial cell | 6 studies | 26% ± 7% | |
| epithelial cell | 6 studies | 23% ± 7% | |
| Mueller cell | 6 studies | 24% ± 9% | |
| neuron | 5 studies | 35% ± 13% | |
| endothelial cell of lymphatic vessel | 4 studies | 25% ± 4% | |
| fibroblast | 4 studies | 22% ± 7% | |
| GABAergic interneuron | 3 studies | 30% ± 4% | |
| retinal ganglion cell | 3 studies | 25% ± 6% | |
| ependymal cell | 3 studies | 28% ± 11% | |
| pericyte | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1258.84 | 577 / 578 | 100% | 10.30 | 1150 / 1155 |
| esophagus | 100% | 1114.05 | 1444 / 1445 | 99% | 12.98 | 182 / 183 |
| brain | 100% | 1440.18 | 2634 / 2642 | 100% | 10.13 | 702 / 705 |
| ovary | 100% | 1247.89 | 180 / 180 | 99% | 8.21 | 424 / 430 |
| stomach | 100% | 849.52 | 359 / 359 | 99% | 10.35 | 282 / 286 |
| breast | 100% | 1383.71 | 459 / 459 | 99% | 11.98 | 1102 / 1118 |
| thymus | 100% | 1359.32 | 653 / 653 | 99% | 10.71 | 596 / 605 |
| intestine | 100% | 1175.00 | 966 / 966 | 98% | 8.61 | 516 / 527 |
| adrenal gland | 100% | 2088.32 | 258 / 258 | 97% | 11.76 | 224 / 230 |
| prostate | 100% | 1118.13 | 244 / 245 | 97% | 9.39 | 489 / 502 |
| kidney | 100% | 992.01 | 89 / 89 | 97% | 11.20 | 870 / 901 |
| bladder | 100% | 1292.57 | 21 / 21 | 95% | 7.32 | 481 / 504 |
| pancreas | 97% | 575.14 | 319 / 328 | 98% | 8.26 | 174 / 178 |
| uterus | 100% | 1626.85 | 170 / 170 | 95% | 8.00 | 436 / 459 |
| skin | 100% | 1387.17 | 1806 / 1809 | 94% | 12.17 | 442 / 472 |
| liver | 100% | 541.55 | 226 / 226 | 81% | 4.40 | 330 / 406 |
| adipose | 100% | 1479.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1650.07 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1138.52 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1016.21 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.48 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 8.54 | 44 / 45 |
| heart | 95% | 711.81 | 819 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 4.98 | 23 / 29 |
| eye | 0% | 0 | 0 / 0 | 57% | 3.58 | 46 / 80 |
| peripheral blood | 56% | 524.09 | 523 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007601 | Biological process | visual perception |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0018344 | Biological process | protein geranylgeranylation |
| GO_0006612 | Biological process | protein targeting to membrane |
| GO_0007264 | Biological process | small GTPase-mediated signal transduction |
| GO_0005968 | Cellular component | Rab-protein geranylgeranyltransferase complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0005092 | Molecular function | GDP-dissociation inhibitor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004663 | Molecular function | Rab geranylgeranyltransferase activity |
| GO_0005096 | Molecular function | GTPase activator activity |
| Gene name | CHM |
| Protein name | CHM protein (HSD-32) (cDNA FLJ38564 fis, clone HCHON2004359) Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) |
| Synonyms | TCD REP1 |
| Description | FUNCTION: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. . |
| Accessions | Q8N917 ENST00000357749.7 [P24386-1] P24386 ENST00000615443.1 [P24386-2] |