CH25H report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CH25H at tissue level.

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_1903914Biological processnegative regulation of fusion of virus membrane with host plasma membrane
GO_0035754Biological processB cell chemotaxis
GO_0016126Biological processsterol biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0034340Biological processresponse to type I interferon
GO_0090206Biological processnegative regulation of cholesterol metabolic process
GO_0005829Cellular componentcytosol
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005506Molecular functioniron ion binding
GO_0008395Molecular functionsteroid hydroxylase activity
GO_0000254Molecular functionC-4 methylsterol oxidase activity
GO_0005515Molecular functionprotein binding
GO_0001567Molecular functioncholesterol 25-hydroxylase activity

IV. Literature review

[source]
Gene nameCH25H
Protein nameCholesterol 25-hydroxylase (EC 1.14.99.38) (Cholesterol 25-monooxygenase) (h25OH)
Synonyms
DescriptionFUNCTION: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes . Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing . As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication . In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity). .

AccessionsO95992
ENST00000371852.4