CFB | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CFB at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	140154.19	226 / 226	91%	18.96	371 / 406
stomach	98%	4744.26	351 / 359	73%	5.69	208 / 286
intestine	95%	3379.50	921 / 966	66%	4.04	346 / 527
breast	97%	3621.14	443 / 459	64%	6.10	711 / 1118
ovary	62%	1176.18	111 / 180	92%	16.75	394 / 430
pancreas	90%	3533.29	294 / 328	61%	2.64	108 / 178
kidney	97%	5734.94	86 / 89	50%	2.11	452 / 901
esophagus	91%	2319.81	1311 / 1445	55%	4.62	100 / 183
lung	99%	5357.39	575 / 578	42%	2.34	485 / 1155
bladder	100%	1966.71	21 / 21	31%	1.68	154 / 504
prostate	98%	7367.90	240 / 245	22%	1.04	112 / 502
thymus	93%	1958.41	605 / 653	19%	0.62	116 / 605
uterus	76%	1596.79	130 / 170	30%	1.76	139 / 459
blood vessel	99%	3473.34	1319 / 1335	0%	0	0 / 0
adipose	98%	9713.23	1179 / 1204	0%	0	0 / 0
spleen	97%	1664.07	233 / 241	0%	0	0 / 0
adrenal gland	84%	2049.63	216 / 258	0%	0.01	1 / 230
skin	57%	745.98	1030 / 1809	2%	0.06	9 / 472
heart	57%	2152.11	491 / 861	0%	0	0 / 0
brain	26%	282.87	696 / 2642	2%	0.06	15 / 705
tonsil	0%	0	0 / 0	13%	0.53	6 / 45
lymph node	0%	0	0 / 0	7%	0.17	2 / 29
muscle	5%	49.14	44 / 803	0%	0	0 / 0
peripheral blood	3%	150.00	27 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006957	Biological process	complement activation, alternative pathway
GO_0006956	Biological process	complement activation
GO_0006508	Biological process	proteolysis
GO_0009617	Biological process	response to bacterium
GO_0005615	Cellular component	extracellular space
GO_0072562	Cellular component	blood microparticle
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0004252	Molecular function	serine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0001848	Molecular function	complement binding

Gene name	CFB
Protein name	Complement factor B Complement factor B (EC 3.4.21.47) (C3/C5 convertase) Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment] Complement factor B preproprotein
Synonyms	BFD BF
Description	FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Accessions	A0A0G2JH38 H7C5H1 ENST00000419920.2 A0A8V8TNU0 F8WBL9 ENST00000417261.5 [P00751-1] A0A8V8TMI9 ENST00000425368.7 [P00751-1] ENST00000419411.6 [P00751-1] W8VT81 ENST00000698628.1 ENST00000455591.5 [P00751-1] ENST00000424727.5 [P00751-1] ENST00000427888.2 [P00751-1] ENST00000375455.7 P00751 ENST00000436692.2 [P00751-1] ENST00000375443.3 ENST00000497841.6 ENST00000399981.5 ENST00000460718.5 ENST00000483004.2 ENST00000433503.2 [P00751-1] ENST00000426239.1 [P00751-1]

CFB report