CETN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0000278Biological processmitotic cell cycle
GO_0051028Biological processmRNA transport
GO_0006289Biological processnucleotide-excision repair
GO_0051301Biological processcell division
GO_0015031Biological processprotein transport
GO_0007099Biological processcentriole replication
GO_0032465Biological processregulation of cytokinesis
GO_0032391Cellular componentphotoreceptor connecting cilium
GO_0097729Cellular component9+2 motile cilium
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0070390Cellular componenttranscription export complex 2
GO_0005814Cellular componentcentriole
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005829Cellular componentcytosol
GO_0071942Cellular componentXPC complex
GO_0036064Cellular componentciliary basal body
GO_0045177Cellular componentapical part of cell
GO_0005634Cellular componentnucleus
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0032795Molecular functionheterotrimeric G-protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCETN2
Protein nameCentrin-2 (Caltractin isoform 1)
SynonymsCALT
CEN2
DescriptionFUNCTION: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. .

AccessionsENST00000709996.1
ENST00000370277.5
P41208