CES2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0009056Biological processcatabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0047374Molecular functionmethylumbelliferyl-acetate deacetylase activity
GO_0106435Molecular functioncarboxylesterase activity
GO_0052689Molecular functioncarboxylic ester hydrolase activity

IV. Literature review

[source]
Gene nameCES2
Protein nameCarboxylic ester hydrolase (EC 3.1.1.-)
Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)
Carboxylesterase 2
SynonymsICE
DescriptionFUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs . Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine . Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol . Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins . .

AccessionsENST00000417689.6 [O00748-2]
H3BUN5
J3QSC0
O00748
Q6IPK9
ENST00000561697.5
ENST00000568470.6
J3QLP1
ENST00000564420.1
ENST00000317091.10 [O00748-1]
ENST00000570032.2
Q4G0E9