CES1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	17 studies	33% ± 17%	Explore
ciliated cell	15 studies	47% ± 20%	Explore
classical monocyte	10 studies	22% ± 5%	Explore
smooth muscle cell	7 studies	23% ± 9%	Explore
alveolar macrophage	6 studies	39% ± 11%	Explore
macrophage	5 studies	37% ± 19%	Explore
myofibroblast cell	5 studies	40% ± 14%	Explore
hepatocyte	4 studies	74% ± 14%	Explore
duct epithelial cell	3 studies	31% ± 7%	Explore
pericyte	3 studies	26% ± 7%	Explore
cholangiocyte	3 studies	47% ± 18%	Explore
endothelial cell	3 studies	38% ± 17%	Explore
type II pneumocyte	3 studies	21% ± 4%	Explore
monocyte	3 studies	25% ± 4%	Explore
connective tissue cell	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	20% ± 5%	Explore
liver	3 studies	46% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	40542.49	226 / 226	96%	1857.92	388 / 406
lung	100%	10909.22	578 / 578	76%	342.35	879 / 1155
prostate	89%	2460.52	217 / 245	79%	30.05	396 / 502
bladder	100%	3856.00	21 / 21	28%	99.91	141 / 504
uterus	92%	3292.24	157 / 170	21%	64.59	95 / 459
esophagus	83%	2846.06	1198 / 1445	30%	188.45	55 / 183
breast	83%	2958.83	382 / 459	29%	10.93	328 / 1118
intestine	81%	3627.30	780 / 966	28%	21.51	150 / 527
blood vessel	98%	4287.01	1308 / 1335	0%	0	0 / 0
adipose	87%	4800.25	1046 / 1204	0%	0	0 / 0
pancreas	10%	125.85	34 / 328	76%	61.47	135 / 178
heart	81%	2178.24	699 / 861	0%	0	0 / 0
spleen	81%	2234.93	195 / 241	0%	0	0 / 0
stomach	39%	1387.35	140 / 359	33%	30.20	95 / 286
ovary	63%	1233.94	114 / 180	4%	0.95	18 / 430
thymus	39%	530.44	255 / 653	26%	10.06	159 / 605
skin	52%	776.70	937 / 1809	7%	2.60	33 / 472
adrenal gland	41%	782.15	107 / 258	10%	8.66	24 / 230
peripheral blood	50%	1062.93	468 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	38%	16.97	11 / 29
kidney	16%	165.84	14 / 89	15%	6.18	134 / 901
eye	0%	0	0 / 0	10%	2.70	8 / 80
tonsil	0%	0	0 / 0	9%	22.53	4 / 45
brain	0%	3.59	9 / 2642	3%	0.72	20 / 705
muscle	2%	23.58	18 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0010887	Biological process	negative regulation of cholesterol storage
GO_0030855	Biological process	epithelial cell differentiation
GO_0008203	Biological process	cholesterol metabolic process
GO_0043691	Biological process	reverse cholesterol transport
GO_0090205	Biological process	positive regulation of cholesterol metabolic process
GO_0016042	Biological process	lipid catabolic process
GO_0090122	Biological process	cholesterol ester hydrolysis involved in cholesterol transport
GO_0120188	Biological process	regulation of bile acid secretion
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0051791	Biological process	medium-chain fatty acid metabolic process
GO_0071397	Biological process	cellular response to cholesterol
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0070857	Biological process	regulation of bile acid biosynthetic process
GO_0009636	Biological process	response to toxic substance
GO_0006695	Biological process	cholesterol biosynthetic process
GO_0042632	Biological process	cholesterol homeostasis
GO_0005811	Cellular component	lipid droplet
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0106435	Molecular function	carboxylesterase activity
GO_0052689	Molecular function	carboxylic ester hydrolase activity
GO_0047374	Molecular function	methylumbelliferyl-acetate deacetylase activity
GO_0004771	Molecular function	sterol esterase activity

IV. Literature review

[source]

Gene name	CES1
Protein name	Carboxylesterase 1 Liver carboxylesterase 1 Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
Synonyms	CES2 SES1
Description	FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs . Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester . Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine . Catalyzes the transesterification of cocaine to form cocaethylene . Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate . Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins . Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process . First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile . .
Accessions	A0A140TA63 ENST00000563241.5 ENST00000574235.1 ENST00000422046.6 [P23141-3] ENST00000360526.8 [P23141-2] H3BQR4 H3BQV8 ENST00000361503.8 [P23141-1] ENST00000561966.2 ENST00000576185.1 ENST00000569260.1 ENST00000574513.5 H3BSU0 P23141 ENST00000565568.1 ENST00000576783.5 ENST00000571922.5

CES1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review