CEP164 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0006281Biological processDNA repair
GO_0051301Biological processcell division
GO_0005814Cellular componentcentriole
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005813Cellular componentcentrosome
GO_0005615Cellular componentextracellular space
GO_0097539Cellular componentciliary transition fiber
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCEP164
Protein nameCentrosomal protein 164
Centrosomal protein of 164 kDa (Cep164)
Alternative protein CEP164
SynonymsNPHP15
KIAA1052
DescriptionFUNCTION: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. .

AccessionsENST00000533570.1
ENST00000639320.1
E9PI05
ENST00000533153.5
ENST00000525734.5
A0A1W2PQ68
ENST00000525416.5
Q9UPV0
L8E8L4
ENST00000527609.5
ENST00000278935.8 [Q9UPV0-1]
E9PR73
E9PIM2
E9PLS8