CEP152 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CEP152 at tissue level.

III. Associated gene sets

GO_0098535Biological processde novo centriole assembly involved in multi-ciliated epithelial cell differentiation
GO_0030030Biological processcell projection organization
GO_0007099Biological processcentriole replication
GO_0051298Biological processcentrosome duplication
GO_0005814Cellular componentcentriole
GO_0120099Cellular componentprocentriole replication complex
GO_0005813Cellular componentcentrosome
GO_0098536Cellular componentdeuterosome
GO_0000242Cellular componentpericentriolar material
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0120098Cellular componentprocentriole
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCEP152
Protein nameCentrosomal protein 152
Centrosomal protein of 152 kDa (Cep152)
CEP152 protein
SynonymsKIAA0912
DescriptionFUNCTION: Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication . Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation . Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure . Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles . .

AccessionsQ3B7A2
ENST00000561245.1
A0A075B719
ENST00000325747.9 [O94986-1]
ENST00000399334.7 [O94986-3]
ENST00000558591.1
ENST00000560322.5
ENST00000380950.7 [O94986-4]
O94986
H0YMG1
H0YN91