CENPA | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CENPA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	99%	346.12	1783 / 1809	94%	17.06	444 / 472
lung	74%	46.06	430 / 578	85%	17.57	982 / 1155
intestine	55%	80.07	534 / 966	95%	19.35	502 / 527
stomach	47%	48.68	168 / 359	95%	17.60	273 / 286
esophagus	45%	99.75	654 / 1445	97%	21.78	177 / 183
breast	57%	33.37	263 / 459	82%	14.19	913 / 1118
bladder	19%	8.48	4 / 21	92%	20.54	463 / 504
ovary	11%	9.72	20 / 180	98%	24.39	423 / 430
uterus	12%	5.94	20 / 170	97%	31.66	447 / 459
lymph node	0%	0	0 / 0	100%	29.96	29 / 29
tonsil	0%	0	0 / 0	100%	30.56	45 / 45
ureter	0%	0	0 / 0	100%	7.57	1 / 1
spleen	98%	163.45	236 / 241	0%	0	0 / 0
adrenal gland	55%	26.52	142 / 258	15%	2.07	35 / 230
pancreas	9%	3.52	31 / 328	61%	6.46	108 / 178
peripheral blood	65%	370.78	604 / 929	0%	0	0 / 0
liver	15%	11.51	35 / 226	44%	4.67	180 / 406
adipose	58%	39.58	698 / 1204	0%	0	0 / 0
prostate	32%	12.60	78 / 245	16%	1.35	79 / 502
brain	4%	1.60	111 / 2642	36%	5.48	257 / 705
kidney	26%	17.65	23 / 89	9%	1.02	82 / 901
thymus	20%	8.48	129 / 653	14%	4.53	85 / 605
heart	33%	22.18	284 / 861	0%	0	0 / 0
blood vessel	20%	8.08	266 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.87	9 / 80
muscle	3%	0.67	21 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0071459	Biological process	protein localization to chromosome, centromeric region
GO_0051382	Biological process	kinetochore assembly
GO_0000132	Biological process	establishment of mitotic spindle orientation
GO_0000281	Biological process	mitotic cytokinesis
GO_0034080	Biological process	CENP-A containing chromatin assembly
GO_0061644	Biological process	protein localization to CENP-A containing chromatin
GO_0000775	Cellular component	chromosome, centromeric region
GO_0000786	Cellular component	nucleosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0043505	Cellular component	CENP-A containing nucleosome
GO_0005721	Cellular component	pericentric heterochromatin
GO_0000779	Cellular component	condensed chromosome, centromeric region
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0030527	Molecular function	structural constituent of chromatin
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

Gene name	CENPA
Protein name	Centromere protein A Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Synonyms
Description	FUNCTION: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes . Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore . The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 . May serve as an epigenetic mark that propagates centromere identity through replication and cell division . Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis . .
Accessions	ENST00000335756.9 [P49450-1] F8WD88 ENST00000419525.5 ENST00000233505.12 [P49450-2] P49450

CENPA report