CECR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097194Biological processexecution phase of apoptosis
GO_0016192Biological processvesicle-mediated transport
GO_0061640Biological processcytoskeleton-dependent cytokinesis
GO_0006309Biological processapoptotic DNA fragmentation
GO_0007338Biological processsingle fertilization
GO_0060122Biological processinner ear receptor cell stereocilium organization
GO_0090102Biological processcochlea development
GO_0007010Biological processcytoskeleton organization
GO_0001842Biological processneural fold formation
GO_0006338Biological processchromatin remodeling
GO_0001843Biological processneural tube closure
GO_0090537Cellular componentCERF complex
GO_0000791Cellular componenteuchromatin
GO_0005634Cellular componentnucleus
GO_0140658Molecular functionATP-dependent chromatin remodeler activity

IV. Literature review

[source]
Gene nameCECR2
Protein nameCat eye syndrome critical region protein 2
Alternative protein CECR2
CECR2 histone acetyl-lysine reader
Chromatin remodeling regulator CECR2 (Cat eye syndrome critical region protein 2)
SynonymsKIAA1740
DescriptionFUNCTION: Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . The complexes do not have the ability to slide mononucleosomes to the center of a DNA template . The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex . Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated . May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis . .

AccessionsENST00000262608.13 [Q9BXF3-3]
ENST00000400585.7
A0A087WT21
ENST00000612582.1
ENST00000355219.4
ENST00000262608
H0Y2Z1
ENST00000342247.10 [Q9BXF3-1]
Q9BXF3
L8E8W0
A0A0R4J2E1
B7WPH3