CDC25A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CDC25A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDC25A at tissue level.

III. Associated gene sets

GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0008283Biological processcell population proliferation
GO_0034644Biological processcellular response to UV
GO_0009314Biological processresponse to radiation
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301Biological processcell division
GO_0045740Biological processpositive regulation of DNA replication
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0110032Biological processpositive regulation of G2/MI transition of meiotic cell cycle
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0019901Molecular functionprotein kinase binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameCDC25A
Protein nameM-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
M-phase inducer phosphatase (EC 3.1.3.48)
Cell division cycle 25A
Synonyms
DescriptionFUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression . Directly dephosphorylates CDK1 and stimulates its kinase activity . Also dephosphorylates CDK2 in complex with cyclin-E, in vitro . .

FUNCTION: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. .

AccessionsENST00000302506.8 [P30304-1]
ENST00000351231.7 [P30304-2]
C9JH94
D8KXX0
ENST00000437972.1
C9JFR5
P30304
ENST00000443342.5