CDC23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0051445Biological processregulation of meiotic cell cycle
GO_0000278Biological processmitotic cell cycle
GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0007091Biological processmetaphase/anaphase transition of mitotic cell cycle
GO_0007096Biological processregulation of exit from mitosis
GO_0051301Biological processcell division
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0007346Biological processregulation of mitotic cell cycle
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDC23
Protein nameCell division cycle 23
Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)
SynonymsANAPC8
DescriptionFUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .

AccessionsQ9UJX2
H0Y936
ENST00000505120.1
ENST00000394884.7 [Q9UJX2-2]
D6RBY8
ENST00000394886.7 [Q9UJX2-1]
D6RCF8
ENST00000483961.6
ENST00000511383.5