CDC14B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0006281Biological processDNA repair
GO_0006470Biological processprotein dephosphorylation
GO_0007096Biological processregulation of exit from mitosis
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0032467Biological processpositive regulation of cytokinesis
GO_0005730Cellular componentnucleolus
GO_0072686Cellular componentmitotic spindle
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0017018Molecular functionmyosin phosphatase activity
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameCDC14B
Protein nameAlternative protein CDC14B
Cell division cycle 14B
Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)
Synonyms
DescriptionFUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. .

AccessionsH7C3U8
ENST00000415608.1
H0Y577
Q5JU07
ENST00000474602.5 [O60729-3]
ENST00000375242.7 [O60729-5]
O60729
ENST00000463569.5 [O60729-4]
A0A9L9PY50
ENST00000412285.6
ENST00000375241.6 [O60729-1]
L8E9I0
ENST00000452280.5
ENST00000375240.7 [O60729-2]
ENST00000481149.2