CD177 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CD177 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD177 at tissue level.

III. Associated gene sets

GO_1990266Biological processneutrophil migration
GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0045087Biological processinnate immune response
GO_2001044Biological processregulation of integrin-mediated signaling pathway
GO_0007155Biological processcell adhesion
GO_0034394Biological processprotein localization to cell surface
GO_0043315Biological processpositive regulation of neutrophil degranulation
GO_0072672Biological processneutrophil extravasation
GO_0030100Biological processregulation of endocytosis
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0045217Biological processcell-cell junction maintenance
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0030667Cellular componentsecretory granule membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0044853Cellular componentplasma membrane raft
GO_0070821Cellular componenttertiary granule membrane
GO_0098552Cellular componentside of membrane
GO_0030027Cellular componentlamellipodium
GO_0005178Molecular functionintegrin binding
GO_0002020Molecular functionprotease binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD177
Protein namePutative CD177 protein
CD177 molecule
CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)
CD177
SynonymsPRV1
UNQ595/PRO1181
NB1
DescriptionFUNCTION: In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production . In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration . Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro . However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo . Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils . By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis . .

AccessionsQ8N6Q3
Q1T7A3
D2N288
ENST00000618265.5
ENST00000378012.3 [Q8N6Q3-3]
A0A087X113
ENST00000607855.5
A0A087WVM2