CCP110 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903723Biological processnegative regulation of centriole elongation
GO_1902018Biological processnegative regulation of cilium assembly
GO_0032053Biological processciliary basal body organization
GO_0045724Biological processpositive regulation of cilium assembly
GO_0007099Biological processcentriole replication
GO_0032465Biological processregulation of cytokinesis
GO_0051298Biological processcentrosome duplication
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCP110
Protein nameCentriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110)
Centriolar coiled-coil protein 110
SynonymsCP110
KIAA0419
CEP110
DescriptionFUNCTION: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation . Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 . .

AccessionsENST00000396212.6 [O43303-2]
H3BVH3
I3L262
ENST00000694978.1 [O43303-2]
ENST00000562083.1
ENST00000565376.2
ENST00000561888.1
O43303
H3BMS1
ENST00000396208.4 [O43303-2]
ENST00000381396.9 [O43303-1]