CCNT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0007519Biological processskeletal muscle tissue development
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0019085Biological processearly viral transcription
GO_0051301Biological processcell division
GO_0019086Biological processlate viral transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0061575Molecular functioncyclin-dependent protein serine/threonine kinase activator activity
GO_0003682Molecular functionchromatin binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0097322Molecular function7SK snRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCNT2
Protein nameCyclin T2
Cyclin-T2 (CycT2)
Synonyms
DescriptionFUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) . The activity of this complex is regulated by binding with 7SK snRNA . Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 . Involved in early embryo development (By similarity). .; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. .

AccessionsENST00000446247.5
ENST00000264157.10 [O60583-1]
F2Z2C9
ENST00000452839.5
H7BZ27
ENST00000438691.1
H7C411
C9JUL2
ENST00000295238.11 [O60583-2]
O60583
F8WDY7
ENST00000417175.1
ENST00000452521.1
ENST00000419781.5