I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 19 studies | 65% ± 21% | |
| deuterosomal cell | 3 studies | 25% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 19 studies | 65% ± 21% | |
| deuterosomal cell | 3 studies | 25% ± 1% |
Insufficient scRNA-seq data for expression of CCDC78 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 778.29 | 2629 / 2642 | 77% | 5.40 | 545 / 705 |
| lung | 94% | 1183.61 | 543 / 578 | 51% | 3.72 | 584 / 1155 |
| prostate | 89% | 137.38 | 219 / 245 | 52% | 3.70 | 260 / 502 |
| kidney | 92% | 160.83 | 82 / 89 | 40% | 2.40 | 358 / 901 |
| ovary | 62% | 71.61 | 112 / 180 | 67% | 4.97 | 287 / 430 |
| breast | 59% | 82.48 | 272 / 459 | 70% | 6.62 | 778 / 1118 |
| uterus | 82% | 263.75 | 139 / 170 | 44% | 3.12 | 204 / 459 |
| intestine | 74% | 140.28 | 714 / 966 | 47% | 2.46 | 247 / 527 |
| skin | 44% | 44.44 | 787 / 1809 | 72% | 4.65 | 338 / 472 |
| adrenal gland | 26% | 46.24 | 67 / 258 | 78% | 8.75 | 179 / 230 |
| spleen | 100% | 401.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.94 | 1 / 1 |
| bladder | 62% | 64.57 | 13 / 21 | 36% | 1.67 | 179 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 5.03 | 27 / 29 |
| thymus | 64% | 75.59 | 421 / 653 | 24% | 2.21 | 146 / 605 |
| stomach | 46% | 42.13 | 164 / 359 | 32% | 1.34 | 91 / 286 |
| eye | 0% | 0 | 0 / 0 | 69% | 3.20 | 55 / 80 |
| esophagus | 43% | 39.99 | 617 / 1445 | 25% | 1.07 | 45 / 183 |
| pancreas | 9% | 7.75 | 28 / 328 | 53% | 2.37 | 94 / 178 |
| peripheral blood | 55% | 157.18 | 513 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 51% | 52.14 | 681 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 40% | 39.55 | 477 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 1.73 | 15 / 45 |
| liver | 2% | 1.94 | 4 / 226 | 13% | 0.79 | 52 / 406 |
| heart | 15% | 12.33 | 125 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0098535 | Biological process | de novo centriole assembly involved in multi-ciliated epithelial cell differentiation |
| GO_0003009 | Biological process | skeletal muscle contraction |
| GO_0030030 | Biological process | cell projection organization |
| GO_0005814 | Cellular component | centriole |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0098536 | Cellular component | deuterosome |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| Gene name | CCDC78 |
| Protein name | Coiled-coil domain containing 78 Coiled-coil domain-containing protein 78 (hsCCDC78) |
| Synonyms | C16orf25 JFP10 hCG_1779871 |
| Description | FUNCTION: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. . |
| Accessions | A0A494C131 A2IDD5 H3BLT8 ENST00000293889.10 [A2IDD5-1] ENST00000650995.1 ENST00000345165.10 |
