CCDC22 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCDC22 at tissue level.

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0007253Biological processcytoplasmic sequestering of NF-kappaB
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0006878Biological processintracellular copper ion homeostasis
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032456Biological processendocytic recycling
GO_0006893Biological processGolgi to plasma membrane transport
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0005575Cellular componentcellular_component
GO_0005813Cellular componentcentrosome
GO_0005768Cellular componentendosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding
GO_0097602Molecular functioncullin family protein binding

IV. Literature review

[source]
Gene nameCCDC22
Protein nameCoiled-coil domain-containing protein 22
SynonymsCXorf37
JM1
DescriptionFUNCTION: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 . Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 . Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes . .; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. .

AccessionsO60826
ENST00000376227.4