CCDC134 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CCDC134 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCDC134 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0021591Biological processventricular system development
GO_0030278Biological processregulation of ossification
GO_1990402Biological processembryonic liver development
GO_0035162Biological processembryonic hemopoiesis
GO_0001890Biological processplacenta development
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCDC134
Protein nameCoiled-coil domain-containing protein 134
Coiled-coil domain containing 134
Synonyms
DescriptionFUNCTION: In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function . Enhances cytotoxic anti-tumor activity of CD8(+) T cells . May inhibit ERK and JNK signaling activity . May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling . Has a critical role in the regulation of osteogenesis and bone development . .; FUNCTION: In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. .

AccessionsB0QY51
Q9H6E4
ENST00000255784.6
ENST00000402061.7