CBR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019371Biological processcyclooxygenase pathway
GO_0006805Biological processxenobiotic metabolic process
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0008211Biological processglucocorticoid metabolic process
GO_0030855Biological processepithelial cell differentiation
GO_0042373Biological processvitamin K metabolic process
GO_0070062Cellular componentextracellular exosome
GO_1903561Cellular componentextracellular vesicle
GO_0005829Cellular componentcytosol
GO_0004090Molecular functioncarbonyl reductase (NADPH) activity
GO_0047021Molecular function15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO_0008106Molecular functionalcohol dehydrogenase (NADP+) activity
GO_0050221Molecular functionprostaglandin E2 9-reductase activity
GO_0016655Molecular functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO_0160163Molecular functionS-nitrosoglutathione reductase (NADPH) activity
GO_0016616Molecular functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO_0047020Molecular function15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

IV. Literature review

[source]
Gene nameCBR1
Protein nameCarbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)
Carbonyl reductase 1
SynonymsSDR21C1
CBR
CRN
DescriptionFUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol . Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione . In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue . .

AccessionsE9PQ63
A8MTM1
ENST00000530908.5 [P16152-2]
ENST00000290349.11 [P16152-1]
ENST00000399191.3
ENST00000439427.2
P16152