CBLL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007162Biological processnegative regulation of cell adhesion
GO_0045807Biological processpositive regulation of endocytosis
GO_0030335Biological processpositive regulation of cell migration
GO_0006397Biological processmRNA processing
GO_0030155Biological processregulation of cell adhesion
GO_0098609Biological processcell-cell adhesion
GO_0016607Cellular componentnuclear speck
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCBLL1
Protein nameCbl proto-oncogene like 1
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)
Alternative protein CBLL1
SynonymsHAKAI
RNF188
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Its function in the WMM complex is unknown . .

AccessionsL8ECK4
C9J2P9
A0A8V8TMY5
C9K074
F8WEM5
Q75N03
ENST00000440859.8 [Q75N03-1]
ENST00000420796.1
ENST00000415884.6
ENST00000432748.5
ENST00000222597.7 [Q75N03-2]
ENST00000698938.1