CAVIN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CAVIN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CAVIN4 at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0030154Biological processcell differentiation
GO_0007517Biological processmuscle organ development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0042383Cellular componentsarcolemma
GO_0016528Cellular componentsarcoplasm
GO_0005829Cellular componentcytosol
GO_0030018Cellular componentZ disc
GO_0005886Cellular componentplasma membrane
GO_0005901Cellular componentcaveola
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAVIN4
Protein nameCaveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein)
SynonymsMURC
DescriptionFUNCTION: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway . .

AccessionsQ5BKX8
ENST00000307584.6