CAMSAP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CAMSAP3 at tissue level.

III. Associated gene sets

GO_0045198Biological processestablishment of epithelial cell apical/basal polarity
GO_0001701Biological processin utero embryonic development
GO_0030951Biological processestablishment or maintenance of microtubule cytoskeleton polarity
GO_0033043Biological processregulation of organelle organization
GO_0031175Biological processneuron projection development
GO_0043111Biological processreplication fork arrest
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0034453Biological processmicrotubule anchoring
GO_0098840Biological processprotein transport along microtubule
GO_1903358Biological processregulation of Golgi organization
GO_0030334Biological processregulation of cell migration
GO_0051893Biological processregulation of focal adhesion assembly
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0003341Biological processcilium movement
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0090136Biological processepithelial cell-cell adhesion
GO_0031113Biological processregulation of microtubule polymerization
GO_0000076Biological processDNA replication checkpoint signaling
GO_0045218Biological processzonula adherens maintenance
GO_0005915Cellular componentzonula adherens
GO_0005813Cellular componentcentrosome
GO_0031514Cellular componentmotile cilium
GO_0036449Cellular componentmicrotubule minus-end
GO_0031298Cellular componentreplication fork protection complex
GO_0005930Cellular componentaxoneme
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0003677Molecular functionDNA binding
GO_0051011Molecular functionmicrotubule minus-end binding
GO_0030507Molecular functionspectrin binding
GO_0051015Molecular functionactin filament binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAMSAP3
Protein nameCalmodulin-regulated spectrin-associated protein 3 (Protein Nezha)
SynonymsKIAA1543
DescriptionFUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization . Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization . Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization . In addition, it also reduces the velocity of microtubule polymerization . Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites . Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation . Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration . Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome . Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes . Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal . Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). .

AccessionsQ9P1Y5
ENST00000160298.9 [Q9P1Y5-1]
ENST00000446248.4 [Q9P1Y5-2]