CALHM1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CALHM1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CALHM1 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0050917Biological processsensory perception of umami taste
GO_0015867Biological processATP transport
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0050913Biological processsensory perception of bitter taste
GO_0051291Biological processprotein heterooligomerization
GO_0006812Biological processmonoatomic cation transport
GO_1904669Biological processATP export
GO_0050916Biological processsensory perception of sweet taste
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005244Molecular functionvoltage-gated monoatomic ion channel activity
GO_0042802Molecular functionidentical protein binding
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0005515Molecular functionprotein binding
GO_0005227Molecular functioncalcium-activated cation channel activity

IV. Literature review

[source]
Gene nameCALHM1
Protein nameCalcium homeostasis modulator protein 1 (Protein FAM26C)
SynonymsFAM26C
DescriptionFUNCTION: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration . Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions . Acts as an activator of the ERK1 and ERK2 cascade . Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum . May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner . .

AccessionsENST00000329905.6
Q8IU99