CAD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CAD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CAD at tissue level.

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0014075Biological processresponse to amine
GO_0006805Biological processxenobiotic metabolic process
GO_0007507Biological processheart development
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0032868Biological processresponse to insulin
GO_0006541Biological processglutamine metabolic process
GO_0001889Biological processliver development
GO_0031100Biological processanimal organ regeneration
GO_0006228Biological processUTP biosynthetic process
GO_0007565Biological processfemale pregnancy
GO_0042594Biological processresponse to starvation
GO_0006207Biological process'de novo' pyrimidine nucleobase biosynthetic process
GO_0044205Biological process'de novo' UMP biosynthetic process
GO_0006225Biological processUDP biosynthetic process
GO_0007595Biological processlactation
GO_0046777Biological processprotein autophosphorylation
GO_0031000Biological processresponse to caffeine
GO_0051414Biological processresponse to cortisol
GO_0019240Biological processcitrulline biosynthetic process
GO_0016020Cellular componentmembrane
GO_0043195Cellular componentterminal bouton
GO_0032991Cellular componentprotein-containing complex
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004088Molecular functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO_0004087Molecular functioncarbamoyl-phosphate synthase (ammonia) activity
GO_0070335Molecular functionaspartate binding
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0004359Molecular functionglutaminase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004151Molecular functiondihydroorotase activity
GO_0005515Molecular functionprotein binding
GO_0004070Molecular functionaspartate carbamoyltransferase activity

IV. Literature review

[source]
Gene nameCAD
Protein nameCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAD protein
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Uncharacterized protein CAD
Synonyms
DescriptionFUNCTION: Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. .

AccessionsENST00000403525.5
G1UI39
H7BZB3
ENST00000456311.1
ENST00000458503.1
P27708
ENST00000428460.1
Q53SY7
H7C2E4
ENST00000264705.9
H7C3Z5
F8VPD4
Q53SZ4