CACNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0072659Biological processprotein localization to plasma membrane
GO_0045933Biological processpositive regulation of muscle contraction
GO_0098912Biological processmembrane depolarization during atrial cardiac muscle cell action potential
GO_1901385Biological processregulation of voltage-gated calcium channel activity
GO_0007528Biological processneuromuscular junction development
GO_0070509Biological processcalcium ion import
GO_0007268Biological processchemical synaptic transmission
GO_0086045Biological processmembrane depolarization during AV node cell action potential
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0099509Biological processregulation of presynaptic cytosolic calcium ion concentration
GO_1901843Biological processpositive regulation of high voltage-gated calcium channel activity
GO_1904879Biological processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_1990454Cellular componentL-type voltage-gated calcium channel complex
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0098684Cellular componentphotoreceptor ribbon synapse
GO_0086056Molecular functionvoltage-gated calcium channel activity involved in AV node cell action potential
GO_0051015Molecular functionactin filament binding
GO_0086007Molecular functionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity
GO_0099626Molecular functionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

IV. Literature review

[source]
Gene nameCACNB2
Protein nameCalcium voltage-gated channel auxiliary subunit beta 2
Voltage-gated calcium channel beta 2 subunit splice variant CavB2dN4
Voltage-dependent L-type calcium channel subunit beta-2 (Calcium channel voltage-dependent subunit beta 2)
Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)
SynonymsCACNLB2
MYSB
DescriptionFUNCTION: Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force . Involved in membrane targeting of the alpha-1 subunit CACNA1C . .

AccessionsENST00000651928.1
ENST00000352115.10 [Q08289-8]
ENST00000645287.2 [Q08289-9]
ENST00000377329.10 [Q08289-3]
ENST00000377331.8
ENST00000377328.5
ENST00000617363.4
ENST00000615785.4
ENST00000643096.2
ENST00000377319.9 [Q08289-6]
ENST00000650685.1
ENST00000651330.1
A0A494C0C3
ENST00000647168.2
A0A494C1Q6
ENST00000324631.13 [Q08289-1]
Q6TME0
ENST00000377315.6 [Q08289-5]
A0A087WVX5
ENST00000652391.1
ENST00000396576.6 [Q08289-2]
A0A494C0B2
A0A2R8YFX9
A0A494C044
A0A2U3TZM7
Q08289
ENST00000651468.1
A6PVM6
A0A2R8Y555
A0A494C0Z9
ENST00000652478.1
A0A494C184
A0A2R8Y7A6
A0A087WWJ0
ENST00000282343.13 [Q08289-4]
ENST00000644004.1