CACNA1D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0086012Biological processmembrane depolarization during cardiac muscle cell action potential
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0045762Biological processpositive regulation of adenylate cyclase activity
GO_0007605Biological processsensory perception of sound
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_1901379Biological processregulation of potassium ion transmembrane transport
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0098703Biological processcalcium ion import across plasma membrane
GO_1901016Biological processregulation of potassium ion transmembrane transporter activity
GO_0086046Biological processmembrane depolarization during SA node cell action potential
GO_0070509Biological processcalcium ion import
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0006816Biological processcalcium ion transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_1990454Cellular componentL-type voltage-gated calcium channel complex
GO_0030018Cellular componentZ disc
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0086059Molecular functionvoltage-gated calcium channel activity involved SA node cell action potential
GO_0086007Molecular functionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO_0051393Molecular functionalpha-actinin binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0046872Molecular functionmetal ion binding
GO_0030506Molecular functionankyrin binding
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameCACNA1D
Protein nameCalcium voltage-gated channel subunit alpha1 D
Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3)
Voltage-dependent L-type calcium channel subunit alpha
SynonymsCACNL1A2
CCHL1A2
CACH3
CACN4
DescriptionFUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. .

AccessionsENST00000636938.1
A0A1B0GU49
H7C4S8
A0A1B0GW98
A0A1B0GTN0
A0A1B0GVI2
A0A1W2PQ56
ENST00000638120.1
ENST00000645528.2
ENST00000422281.7 [Q01668-3]
A0A1B0GUB6
ENST00000481478.2
A0A1B0GTP8
ENST00000640483.1
ENST00000636627.2
A0A1B0GUH2
ENST00000638129.1
ENST00000636723.1
A0A5F9Z6M3
A0A7G9IPG1
ENST00000481085.5
H0Y879
ENST00000636448.1
ENST00000288139.11 [Q01668-2]
ENST00000637714.1
Q01668
ENST00000636570.1
A0A1B0GUN6
A0A1B0GWF7
ENST00000350061.11 [Q01668-1]
ENST00000637301.1
A0A1B0GWE1
ENST00000637424.1