CACFD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CACFD1 at tissue level.

III. Associated gene sets

GO_0016192Biological processvesicle-mediated transport
GO_0008150Biological processbiological_process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005575Cellular componentcellular_component
GO_0055037Cellular componentrecycling endosome
GO_0008021Cellular componentsynaptic vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCACFD1
Protein nameCalcium channel flower homolog (Calcium channel flower domain-containing protein 1)
Calcium channel flower domain containing 1
SynonymsPSEC0248
UNQ3071/PRO9903
PSEC0107
C9orf7
DescriptionFUNCTION: Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling . In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process . .; FUNCTION: [Isoform 1]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health . During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis . .; FUNCTION: [Isoform 2]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health . During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population . .; FUNCTION: [Isoform 3]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health . During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population . .; FUNCTION: [Isoform 4]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health . During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis . .

AccessionsENST00000316948.9 [Q9UGQ2-1]
Q9UGQ2
ENST00000291722.11 [Q9UGQ2-2]
ENST00000627083.2 [Q9UGQ2-3]
ENST00000630997.2 [Q9UGQ2-4]
ENST00000629431.2 [Q9UGQ2-1]
ENST00000444798.1
F6TGH8
ENST00000625979.2 [Q9UGQ2-2]
ENST00000542192.5 [Q9UGQ2-3]
ENST00000540581.5 [Q9UGQ2-4]