BVES report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BVES at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BVES at tissue level.

III. Associated gene sets

GO_0001921Biological processpositive regulation of receptor recycling
GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0042391Biological processregulation of membrane potential
GO_0007519Biological processskeletal muscle tissue development
GO_0002931Biological processresponse to ischemia
GO_2001135Biological processregulation of endocytic recycling
GO_0007507Biological processheart development
GO_0002027Biological processregulation of heart rate
GO_0040017Biological processpositive regulation of locomotion
GO_0051146Biological processstriated muscle cell differentiation
GO_0060931Biological processsinoatrial node cell development
GO_0016192Biological processvesicle-mediated transport
GO_0060973Biological processcell migration involved in heart development
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0043087Biological processregulation of GTPase activity
GO_0048278Biological processvesicle docking
GO_0007517Biological processmuscle organ development
GO_0008360Biological processregulation of cell shape
GO_0090136Biological processepithelial cell-cell adhesion
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0042383Cellular componentsarcolemma
GO_0031253Cellular componentcell projection membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0030054Cellular componentcell junction
GO_0005901Cellular componentcaveola
GO_0030552Molecular functioncAMP binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBVES
Protein nameBlood vessel epicardial substance (hBVES) (Popeye domain-containing protein 1) (Popeye protein 1)
SynonymsPOPDC1
POP1
DescriptionFUNCTION: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells . Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density . Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. .

AccessionsENST00000314641.10
ENST00000336775.9
Q8NE79
ENST00000446408.2