BSN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_1904071Biological processpresynaptic active zone assembly
GO_0099526Biological processpresynapse to nucleus signaling pathway
GO_0048790Biological processmaintenance of presynaptic active zone structure
GO_0007268Biological processchemical synaptic transmission
GO_0098693Biological processregulation of synaptic vesicle cycle
GO_0097091Biological processsynaptic vesicle clustering
GO_0035418Biological processprotein localization to synapse
GO_0098978Cellular componentglutamatergic synapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0030425Cellular componentdendrite
GO_0098982Cellular componentGABA-ergic synapse
GO_0009986Cellular componentcell surface
GO_0048786Cellular componentpresynaptic active zone
GO_0048788Cellular componentcytoskeleton of presynaptic active zone
GO_0008021Cellular componentsynaptic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0060076Cellular componentexcitatory synapse
GO_0030424Cellular componentaxon
GO_0098683Cellular componentcochlear hair cell ribbon synapse
GO_0044306Cellular componentneuron projection terminus
GO_0005634Cellular componentnucleus
GO_0004857Molecular functionenzyme inhibitor activity
GO_0046872Molecular functionmetal ion binding
GO_0098882Molecular functionstructural constituent of presynaptic active zone

IV. Literature review

[source]
Gene nameBSN
Protein nameProtein bassoon (Zinc finger protein 231)
SynonymsKIAA0434
ZNF231
DescriptionFUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released . After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts . At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). .

AccessionsENST00000296452.5
Q9UPA5