BRSK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_2000807Biological processregulation of synaptic vesicle clustering
GO_0010212Biological processresponse to ionizing radiation
GO_0007269Biological processneurotransmitter secretion
GO_0051298Biological processcentrosome duplication
GO_0006974Biological processDNA damage response
GO_0008306Biological processassociative learning
GO_0009411Biological processresponse to UV
GO_0007409Biological processaxonogenesis
GO_0090176Biological processmicrotubule cytoskeleton organization involved in establishment of planar polarity
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0030182Biological processneuron differentiation
GO_0048167Biological processregulation of synaptic plasticity
GO_0099504Biological processsynaptic vesicle cycle
GO_0010975Biological processregulation of neuron projection development
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0050770Biological processregulation of axonogenesis
GO_0150034Cellular componentdistal axon
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0048786Cellular componentpresynaptic active zone
GO_0008021Cellular componentsynaptic vesicle
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0005634Cellular componentnucleus
GO_0043015Molecular functiongamma-tubulin binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding

IV. Literature review

[source]
Gene nameBRSK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
BR serine/threonine kinase 1
Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
SynonymsSAD1
KIAA1811
SADB
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. .

AccessionsENST00000592539.6
K7EM68
ENST00000590333.5 [Q8TDC3-2]
ENST00000591774.5
ENST00000309383.6 [Q8TDC3-1]
Q8TDC3
ENST00000326848.7
K7EN26
ENST00000585418.1 [Q8TDC3-3]
J3KNK0