BRPF1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BRPF1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BRPF1 at tissue level.

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0050793Biological processregulation of developmental process
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0070776Cellular componentMOZ/MORF histone acetyltransferase complex
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0010698Molecular functionacetyltransferase activator activity
GO_0003677Molecular functionDNA binding
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBRPF1
Protein nameBromodomain and PHD finger containing 1
Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)
Bromodomain and PHD finger containing 1 (Bromodomain and PHD finger containing, 1, isoform CRA_d)
Bromodomain and PHD finger containing 1 (Bromodomain and PHD finger containing, 1, isoform CRA_c)
SynonymsBR140
hCG_21547
DescriptionFUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity . Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) . Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation . Positively regulates the transcription of RUNX1 and RUNX2 . .

AccessionsA0A804HL99
ENST00000682208.1
A0A8C8L8G4
A0A804HJV3
ENST00000684250.1
ENST00000457855.2
ENST00000684333.1 [P55201-3]
ENST00000426583.2
ENST00000672515.2
ENST00000424362.7
A0A804HL48
ENST00000683639.1
A0A804HKK9
ENST00000684573.1
ENST00000682980.1
C9JHC0
A0A804HKY8
A0A8C8KWW5
ENST00000684199.1 [P55201-2]
ENST00000673551.2
A0A804HI52
A0A804HKU6
A0A5F9ZH11
A0A804HIN1
ENST00000433861.6 [P55201-4]
ENST00000672126.2
ENST00000420291.3
ENST00000383829.7 [P55201-2]
ENST00000684223.1
ENST00000684206.1
ENST00000683743.1 [P55201-1]
ENST00000684608.1
A0A5F9ZHW9
ENST00000683423.1
P55201
A0A5F9ZHX4
A0A804HHW3