Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 23% ± 7% | |
| astrocyte | 6 studies | 27% ± 9% | |
| epithelial cell | 5 studies | 28% ± 10% | |
| glutamatergic neuron | 5 studies | 39% ± 18% | |
| oligodendrocyte | 5 studies | 24% ± 3% | |
| ciliated cell | 4 studies | 26% ± 5% | |
| oligodendrocyte precursor cell | 4 studies | 29% ± 8% | |
| interneuron | 4 studies | 32% ± 16% | |
| fibroblast | 3 studies | 17% ± 2% | |
| basal cell | 3 studies | 21% ± 4% | |
| GABAergic neuron | 3 studies | 40% ± 3% | |
| neuron | 3 studies | 27% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3933.99 | 1445 / 1445 | 100% | 19.84 | 183 / 183 |
| prostate | 100% | 5098.01 | 245 / 245 | 100% | 28.10 | 502 / 502 |
| breast | 100% | 4470.26 | 459 / 459 | 100% | 33.30 | 1117 / 1118 |
| bladder | 100% | 3999.43 | 21 / 21 | 100% | 21.56 | 503 / 504 |
| ovary | 100% | 5232.26 | 180 / 180 | 100% | 26.33 | 429 / 430 |
| brain | 100% | 3905.42 | 2637 / 2642 | 100% | 42.29 | 704 / 705 |
| intestine | 100% | 4535.16 | 966 / 966 | 100% | 22.12 | 525 / 527 |
| uterus | 100% | 5533.57 | 170 / 170 | 100% | 29.26 | 457 / 459 |
| thymus | 100% | 6377.65 | 653 / 653 | 100% | 31.06 | 602 / 605 |
| lung | 100% | 3338.44 | 576 / 578 | 100% | 21.57 | 1152 / 1155 |
| stomach | 100% | 3383.86 | 358 / 359 | 100% | 20.00 | 285 / 286 |
| pancreas | 100% | 2933.30 | 327 / 328 | 99% | 21.49 | 177 / 178 |
| adrenal gland | 100% | 3459.18 | 258 / 258 | 99% | 25.96 | 228 / 230 |
| skin | 100% | 3749.42 | 1808 / 1809 | 99% | 26.74 | 466 / 472 |
| kidney | 100% | 3893.10 | 89 / 89 | 98% | 22.25 | 879 / 901 |
| liver | 100% | 2370.79 | 226 / 226 | 95% | 14.25 | 386 / 406 |
| adipose | 100% | 3580.25 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 20.72 | 29 / 29 |
| spleen | 100% | 4808.44 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.39 | 45 / 45 |
| blood vessel | 100% | 3614.93 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2562.20 | 799 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 24.02 | 78 / 80 |
| heart | 97% | 2095.47 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 93% | 2237.41 | 865 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0097067 | Biological process | cellular response to thyroid hormone stimulus |
| GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_2000779 | Biological process | regulation of double-strand break repair |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000812 | Cellular component | Swr1 complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000786 | Cellular component | nucleosome |
| GO_0035267 | Cellular component | NuA4 histone acetyltransferase complex |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0046966 | Molecular function | nuclear thyroid hormone receptor binding |
| GO_0030374 | Molecular function | nuclear receptor coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BRD8 |
| Protein name | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) Bromodomain containing 8 |
| Synonyms | SMAP SMAP2 |
| Description | FUNCTION: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. . |
| Accessions | F8WCS7 ENST00000453824.1 ENST00000254900.10 [Q9H0E9-1] ENST00000418329.5 H7C128 ENST00000506167.5 C9JV05 ENST00000450756.5 F8WBH2 H7C026 ENST00000432618.5 ENST00000427976.1 Q9H0E9 H7C2P4 ENST00000402931.5 ENST00000230901.9 [Q9H0E9-2] F8WDX5 H0YAH7 ENST00000512140.5 ENST00000472478.6 ENST00000428808.5 H0Y8F9 ENST00000441656.5 D6RID0 B5MCW3 H0YA84 H7C179 ENST00000511898.1 ENST00000411594.6 [Q9H0E9-4] ENST00000430331.1 ENST00000454473.5 H7C127 |
