BRD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0071168Biological processprotein localization to chromatin
GO_0035987Biological processendodermal cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0106222Molecular functionlncRNA binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameBRD3
Protein nameBromodomain-containing protein 3 short isoform
Alternative protein BRD3
Bromodomain-containing protein 3 (RING3-like protein)
Bromodomain containing 3
SynonymsKIAA0043
RING3L
DescriptionFUNCTION: Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures . Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation . In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 . Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression . Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). .

AccessionsENST00000371834.6 [Q15059-2]
A0A140F1N4
A9J575
ENST00000433041.1
ENST00000371842.2
Q15059
L8E9I5
ENST00000303407.12 [Q15059-1]
A9J571