Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 7 studies | 19% ± 3% | |
| pericyte | 7 studies | 21% ± 5% | |
| endothelial cell | 7 studies | 25% ± 9% | |
| epithelial cell | 7 studies | 26% ± 13% | |
| smooth muscle cell | 6 studies | 19% ± 5% | |
| neuron | 6 studies | 33% ± 18% | |
| myofibroblast cell | 5 studies | 19% ± 3% | |
| classical monocyte | 4 studies | 21% ± 5% | |
| connective tissue cell | 4 studies | 25% ± 6% | |
| ciliated cell | 4 studies | 27% ± 6% | |
| glutamatergic neuron | 4 studies | 28% ± 6% | |
| basal cell | 4 studies | 27% ± 12% | |
| plasmacytoid dendritic cell | 4 studies | 22% ± 6% | |
| oligodendrocyte precursor cell | 4 studies | 20% ± 3% | |
| mesothelial cell | 3 studies | 27% ± 15% | |
| neural crest cell | 3 studies | 27% ± 1% | |
| GABAergic neuron | 3 studies | 25% ± 4% | |
| dendritic cell | 3 studies | 24% ± 7% | |
| abnormal cell | 3 studies | 18% ± 1% | |
| goblet cell | 3 studies | 21% ± 4% | |
| interneuron | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2167.76 | 1445 / 1445 | 100% | 23.22 | 183 / 183 |
| stomach | 100% | 1595.27 | 359 / 359 | 100% | 20.62 | 285 / 286 |
| ovary | 100% | 2161.64 | 180 / 180 | 100% | 23.08 | 428 / 430 |
| intestine | 100% | 2416.67 | 966 / 966 | 99% | 19.16 | 524 / 527 |
| prostate | 100% | 2262.91 | 245 / 245 | 99% | 28.91 | 499 / 502 |
| breast | 100% | 2122.21 | 459 / 459 | 99% | 27.51 | 1107 / 1118 |
| brain | 100% | 1675.55 | 2638 / 2642 | 99% | 32.35 | 699 / 705 |
| lung | 100% | 1817.64 | 577 / 578 | 98% | 17.97 | 1137 / 1155 |
| thymus | 100% | 2445.56 | 653 / 653 | 98% | 18.46 | 591 / 605 |
| pancreas | 99% | 1054.52 | 326 / 328 | 98% | 16.06 | 174 / 178 |
| bladder | 100% | 2262.62 | 21 / 21 | 96% | 15.21 | 485 / 504 |
| skin | 100% | 2129.04 | 1808 / 1809 | 96% | 15.70 | 452 / 472 |
| uterus | 100% | 2790.41 | 170 / 170 | 95% | 17.68 | 436 / 459 |
| kidney | 100% | 1273.80 | 89 / 89 | 94% | 12.76 | 844 / 901 |
| adrenal gland | 100% | 2006.75 | 257 / 258 | 90% | 13.45 | 206 / 230 |
| liver | 100% | 971.09 | 226 / 226 | 76% | 7.97 | 310 / 406 |
| adipose | 100% | 1984.05 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2106.78 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1954.87 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1706.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.55 | 1 / 1 |
| heart | 98% | 1155.97 | 846 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 20.97 | 44 / 45 |
| eye | 0% | 0 | 0 / 0 | 95% | 11.81 | 76 / 80 |
| peripheral blood | 86% | 773.31 | 798 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 7.95 | 21 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0071168 | Biological process | protein localization to chromatin |
| GO_0035987 | Biological process | endodermal cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0070577 | Molecular function | lysine-acetylated histone binding |
| GO_0140693 | Molecular function | molecular condensate scaffold activity |
| GO_0106222 | Molecular function | lncRNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | BRD3 |
| Protein name | Bromodomain-containing protein 3 short isoform Alternative protein BRD3 Bromodomain-containing protein 3 (RING3-like protein) Bromodomain containing 3 |
| Synonyms | KIAA0043 RING3L |
| Description | FUNCTION: Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures . Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation . In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 . Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression . Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). . |
| Accessions | ENST00000371834.6 [Q15059-2] A0A140F1N4 A9J575 ENST00000433041.1 ENST00000371842.2 Q15059 L8E9I5 ENST00000303407.12 [Q15059-1] A9J571 |