Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 20 studies | 29% ± 11% | |
| connective tissue cell | 6 studies | 23% ± 4% | |
| pericyte | 6 studies | 27% ± 8% | |
| smooth muscle cell | 4 studies | 24% ± 12% | |
| chondrocyte | 3 studies | 44% ± 3% |
Insufficient scRNA-seq data for expression of BMP5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1603.95 | 578 / 578 | 69% | 8.07 | 801 / 1155 |
| bladder | 95% | 1689.14 | 20 / 21 | 47% | 2.42 | 236 / 504 |
| pancreas | 59% | 77.45 | 193 / 328 | 57% | 3.79 | 101 / 178 |
| stomach | 83% | 134.22 | 299 / 359 | 31% | 1.00 | 90 / 286 |
| intestine | 71% | 530.44 | 688 / 966 | 42% | 1.69 | 222 / 527 |
| breast | 93% | 232.56 | 426 / 459 | 19% | 2.04 | 215 / 1118 |
| muscle | 99% | 336.09 | 798 / 803 | 0% | 0 | 0 / 0 |
| thymus | 92% | 220.41 | 598 / 653 | 7% | 0.15 | 45 / 605 |
| prostate | 62% | 1027.70 | 151 / 245 | 33% | 3.98 | 167 / 502 |
| liver | 77% | 123.21 | 175 / 226 | 15% | 0.45 | 59 / 406 |
| esophagus | 72% | 190.71 | 1044 / 1445 | 18% | 1.20 | 33 / 183 |
| kidney | 70% | 181.07 | 62 / 89 | 18% | 1.03 | 163 / 901 |
| heart | 77% | 270.20 | 664 / 861 | 0% | 0 | 0 / 0 |
| adipose | 59% | 171.94 | 715 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 19% | 20.86 | 49 / 258 | 10% | 1.22 | 24 / 230 |
| blood vessel | 21% | 36.20 | 285 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 1% | 0.45 | 1 / 170 | 16% | 4.50 | 72 / 459 |
| brain | 4% | 12.56 | 116 / 2642 | 10% | 0.84 | 69 / 705 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.34 | 7 / 80 |
| skin | 4% | 4.55 | 81 / 1809 | 4% | 0.53 | 18 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.12 | 3 / 45 |
| ovary | 2% | 1.87 | 3 / 180 | 3% | 0.20 | 12 / 430 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060037 | Biological process | pharyngeal system development |
| GO_0061384 | Biological process | heart trabecula morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0010894 | Biological process | negative regulation of steroid biosynthetic process |
| GO_0003272 | Biological process | endocardial cushion formation |
| GO_0097065 | Biological process | anterior head development |
| GO_0060411 | Biological process | cardiac septum morphogenesis |
| GO_0071676 | Biological process | negative regulation of mononuclear cell migration |
| GO_0060710 | Biological process | chorio-allantoic fusion |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0003344 | Biological process | pericardium morphogenesis |
| GO_0032348 | Biological process | negative regulation of aldosterone biosynthetic process |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_1900006 | Biological process | positive regulation of dendrite development |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0030539 | Biological process | male genitalia development |
| GO_2000065 | Biological process | negative regulation of cortisol biosynthetic process |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_0043569 | Biological process | negative regulation of insulin-like growth factor receptor signaling pathway |
| GO_0048738 | Biological process | cardiac muscle tissue development |
| GO_0001501 | Biological process | skeletal system development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0030902 | Biological process | hindbrain development |
| GO_1902042 | Biological process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0001503 | Biological process | ossification |
| GO_0043583 | Biological process | ear development |
| GO_1905069 | Biological process | allantois development |
| GO_0051216 | Biological process | cartilage development |
| GO_0021502 | Biological process | neural fold elevation formation |
| GO_0007389 | Biological process | pattern specification process |
| GO_0005575 | Cellular component | cellular_component |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031982 | Cellular component | vesicle |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | BMP5 |
| Protein name | Bone morphogenenic protein-5 (Bone morphogenetic protein 5) Bone morphogenetic protein 5 (BMP-5) |
| Synonyms | hCG_21659 |
| Description | FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis . Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 . In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes . Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation . Promotes the expression of HAMP, this is repressed by its interaction with ERFE . . |
| Accessions | M9VUD0 P22003 ENST00000370830.4 [P22003-1] |
