BMP10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BMP10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BMP10 at tissue level.

III. Associated gene sets

GO_0055015Biological processventricular cardiac muscle cell development
GO_0032924Biological processactivin receptor signaling pathway
GO_0060298Biological processpositive regulation of sarcomere organization
GO_0055009Biological processatrial cardiac muscle tissue morphogenesis
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0060347Biological processheart trabecula formation
GO_0010628Biological processpositive regulation of gene expression
GO_1903242Biological processregulation of cardiac muscle hypertrophy in response to stress
GO_0001822Biological processkidney development
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0007155Biological processcell adhesion
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0055010Biological processventricular cardiac muscle tissue morphogenesis
GO_0030509Biological processBMP signaling pathway
GO_0060038Biological processcardiac muscle cell proliferation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007512Biological processadult heart development
GO_2000138Biological processpositive regulation of cell proliferation involved in heart morphogenesis
GO_0030336Biological processnegative regulation of cell migration
GO_0045214Biological processsarcomere organization
GO_0010596Biological processnegative regulation of endothelial cell migration
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0061036Biological processpositive regulation of cartilage development
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0030018Cellular componentZ disc
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0005179Molecular functionhormone activity
GO_0008083Molecular functiongrowth factor activity
GO_0031433Molecular functiontelethonin binding
GO_0033612Molecular functionreceptor serine/threonine kinase binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameBMP10
Protein nameBone morphogenetic protein 10 (BMP-10)
Synonyms
DescriptionFUNCTION: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. .

AccessionsENST00000295379.2
O95393