BICD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0051028Biological processmRNA transport
GO_0051642Biological processcentrosome localization
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0072385Biological processminus-end-directed organelle transport along microtubule
GO_0072393Biological processmicrotubule anchoring at microtubule organizing center
GO_0007018Biological processmicrotubule-based movement
GO_0015031Biological processprotein transport
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005642Cellular componentannulate lamellae
GO_0005813Cellular componentcentrosome
GO_0005794Cellular componentGolgi apparatus
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0034452Molecular functiondynactin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0070840Molecular functiondynein complex binding
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBICD2
Protein nameProtein bicaudal D homolog 2 (Bic-D 2)
BICD2 protein
SynonymsKIAA0699
DescriptionFUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) . Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex . Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). .

AccessionsQ8TD16
ENST00000375512.3 [Q8TD16-1]
Q96FU2
ENST00000356884.11 [Q8TD16-2]