BDH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006635Biological processfatty acid beta-oxidation
GO_0042168Biological processheme metabolic process
GO_0019290Biological processsiderophore biosynthetic process
GO_0030855Biological processepithelial cell differentiation
GO_0006880Biological processintracellular sequestering of iron ion
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0016617Molecular function4-oxoproline reductase activity
GO_0051287Molecular functionNAD binding
GO_0016628Molecular functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO_0003858Molecular function3-hydroxybutyrate dehydrogenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBDH2
Protein name3-hydroxybutyrate dehydrogenase 2
Alternative protein BDH2
Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)
Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.104) (EC 1.1.1.30) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (4-oxo-L-proline reductase) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)
SynonymsDHRS6
UNQ6308/PRO20933
SDR15C1
DescriptionFUNCTION: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines . Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase . .

AccessionsENST00000509245.1
ENST00000506521.5
ENST00000296424.9 [Q9BUT1-1]
L0R823
ENST00000511354.5
D6RFG2
Q9BUT1
D6RBF6
ENST00000504285.5
D6RIR6
D6R9U8