BCKDK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045763Biological processnegative regulation of cellular amino acid metabolic process
GO_0016310Biological processphosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0010906Biological processregulation of glucose metabolic process
GO_0008610Biological processlipid biosynthetic process
GO_0009083Biological processbranched-chain amino acid catabolic process
GO_0009063Biological processamino acid catabolic process
GO_0045252Cellular componentoxoglutarate dehydrogenase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0047323Molecular function[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO_0016301Molecular functionkinase activity
GO_0004740Molecular functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene nameBCKDK
Protein nameBranched chain keto acid dehydrogenase kinase
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4)
Protein-serine/threonine kinase (EC 2.7.11.-)
Synonyms
DescriptionFUNCTION: Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle . Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex . Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively . Recognizes phosphosites having SxxE/D canonical motif . .

AccessionsH3BUV3
ENST00000567676.1
H3BS02
ENST00000484226.2
ENST00000219794.11 [O14874-1]
ENST00000287507.7 [O14874-2]
ENST00000567682.1
ENST00000561755.1
ENST00000567530.5
H3BTL2
H3BNP3
ENST00000394950.7 [O14874-3]
O14874
H3BQP2
ENST00000394951.5 [O14874-1]